A SIG Alert was issued to a portion of Highway 101 near Donovan Road in Santa Maria Tuesday night.
First responders were called to the scene along the southbound lanes at around 9 p.m.
According to initial reports to the California Highway Patrol, vehicles were stopped on the road to assist with a reported collision, although exact details were not immediately available.
CHP reports stated that nearby, a vehicle had crashed into a tree and an additional car was just off the roadway.
Multiple lanes were closed at around 9 p.m. but back open by 10 p.m., according to CHP.
There's still no word on the extent of any injuries.
We will continue to update this story as information becomes available.